Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06EZQ
|
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| Former ID |
DNC007575
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| Drug Name |
GRANULATIMIDE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [528838] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C15H8N4O2
|
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| Canonical SMILES |
C1=CC=C2C(=C1)C3=C4C(=C5C(=C3N2)NC=N5)C(=O)NC4=O
|
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| InChI |
1S/C15H8N4O2/c20-14-9-8-6-3-1-2-4-7(6)18-12(8)13-11(16-5-17-13)10(9)15(21)19-14/h1-5,18H,(H,16,17)(H,19,20,21)
|
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| InChIKey |
LBTREMHIJGMYQN-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [528838] | |
| Pathway Interaction Database | Fanconi anemia pathway | ||||
| p73 transcription factor network | |||||
| ATR signaling pathway | |||||
| Circadian rhythm pathway | |||||
| p53 pathway | |||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
| References | |||||
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