Drug Information

Drug General Information
Drug ID
D06GDH
Former ID
DCL000763
Drug Name
DA-5018
Synonyms
Capsavanil; Davasaicin; Da 5018; KR-25018; Benzeneacetamide, 4-(2-aminoethoxy)-N-(3-(3,4-dimethylphenyl)propyl)-3-methoxy-, monohydrochloride; 2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[3-(3,4-dimethylphenyl)propyl]acetamide; 2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[3-(3,4-dimethylphenyl)propyl]acetamide hydrochloride
Drug Type
Small molecular drug
Indication Diabetic neuropathy; Postherpetic neuralgia [ICD9: 053.19, 250, 250.6, 356.0, 356.8; ICD10:E11.21, G44.847, G53.0, G64, G90.0] Discontinued in Phase 2 [536374]
Company
Dong-A
Structure
Download
2D MOL

3D MOL
Formula
C22H30N2O3
Canonical SMILES
CC1=C(C=C(C=C1)CCCNC(=O)CC2=CC(=C(C=C2)OCCN)OC)C
InChI
1S/C22H30N2O3/c1-16-6-7-18(13-17(16)2)5-4-11-24-22(25)15-19-8-9-20(27-12-10-23)21(14-19)26-3/h6-9,13-14H,4-5,10-12,15,23H2,1-3H3,(H,24,25)
InChIKey
VVMIHZHLNJMAQP-UHFFFAOYSA-N
CAS Number
CAS 147497-64-1
PubChem Compound ID
177287
PubChem Substance ID
10258580, 12015097, 14853047, 33500751, 57395367, 80116897, 103314121, 103982073, 104426270, 129533005, 134339250, 135156555, 137240438, 139051507, 142239930, 189293215, 198940321, 225022236, 231005887, 241036949
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Modulator [1572591]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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