Drug General Information
Drug ID	D06GKL
Former ID	DNC011482
Drug Name	2-Methylamino-succinic acid(NMDA)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531531]
Structure		Download 2D MOL 3D MOL
Formula	C5H9NO4
Canonical SMILES	CNC(CC(=O)O)C(=O)O
InChI	1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChIKey	HOKKHZGPKSLGJE-GSVOUGTGSA-N
PubChem Compound ID	22880
Target and Pathway
Target(s)	NMDA receptor subunit NR1	Target Info	Inhibitor	[531531]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[531531]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[531531]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholismhsa04014:Ras signaling pathway
	Dopaminergic synapse
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascade
WikiPathways	SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
	Alzheimers Disease
References
Ref 531531	J Med Chem. 1990 Oct;33(10):2772-7.2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Ref 531531	J Med Chem. 1990 Oct;33(10):2772-7.2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.

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