Drug General Information |
Drug ID |
D06HRY
|
Former ID |
DNC003939
|
Drug Name |
SNAP-5089
|
Drug Type |
Small molecular drug
|
Indication |
Heart arrhythmia [ICD10:I47-I49]
|
Terminated |
[1],
[2]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C36H40N4O5
|
InChI |
InChI=1S/C36H40N4O5/c1-25-31(33(32(26(2)38-25)35(42)45-3)27-15-17-30(18-16-27)40(43)44)34(41)37-21-10-22-39-23-19-36(20-24-39,28-11-6-4-7-12-28)29-13-8-5-9-14-29/h4-9,11-18,33,38H,10,19-24H2,1-3H3,(H,37,41)/t33-/m1/s1
|
InChIKey |
FIIXCJGBCCCOQQ-MGBGTMOVSA-N
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PubChem Compound ID |
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PubChem Substance ID |
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Target and Pathway |
Target(s) |
Alpha-2B adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
Alpha-1A adrenergic receptor |
Target Info |
Inhibitor |
[4]
|
Alpha-2C adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
Voltage-dependent L-type calcium channel alpha-1D subunit |
Target Info |
Inhibitor |
[5]
|
Alpha-1D adrenergic receptor |
Target Info |
Inhibitor |
[4]
|
Voltage-dependent L-type calcium channel subunit alpha-1C |
Target Info |
Inhibitor |
[3]
|
Alpha-1B adrenergic receptor |
Target Info |
Inhibitor |
[4]
|
Alpha-2A adrenergic receptor |
Target Info |
Inhibitor |
[3]
|
KEGG Pathway
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cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
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Neuroactive ligand-receptor interaction
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AMPK signaling pathway
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Salivary secretionhsa04022:cGMP-PKG signaling pathway
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Neuroactive ligand-receptor interactionhsa04010:MAPK signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Cardiac muscle contraction
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Circadian entrainment
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Cholinergic synapse
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Serotonergic synapse
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GABAergic synapse
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Dopaminergic synapse
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Insulin secretion
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GnRH signaling pathway
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Oxytocin signaling pathway
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Type II diabetes mellitus
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Carbohydrate digestion and absorption
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Alzheimer's disease
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Amphetamine addiction
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Hypertrophic cardiomyopathy (HCM)
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Arrhythmogenic right ventricular cardiomyopathy (ARVC)
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Dilated cardiomyopathyhsa04020:Calcium signaling pathway
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Salivary secretionhsa04010:MAPK signaling pathway
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Long-term potentiation
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NetPath Pathway
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IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Nicotinic acetylcholine receptor signaling pathway
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5HT2 type receptor mediated signaling pathway
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Beta1 adrenergic receptor signaling pathway
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Beta2 adrenergic receptor signaling pathway
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Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Oxytocin receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
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Pathway Interaction Database
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LPA receptor mediated events
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PathWhiz Pathway
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Muscle/Heart Contraction
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Reactome
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Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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G alpha (i) signalling events
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
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G alpha (q) signalling events
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G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
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NCAM1 interactions
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Regulation of insulin secretionR-HSA-390696:Adrenoceptors
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G alpha (12/13) signalling eventsR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
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Surfactant metabolism
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WikiPathways
|
Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Gastrin-CREB signalling pathway via PKC and MAPK
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Endothelin Pathways
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GPCR downstream signaling
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AMPK SignalingWP58:Monoamine GPCRs
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Integration of energy metabolism
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GPCR downstream signalingWP536:Calcium Regulation in the Cardiac Cell
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Arrhythmogenic Right Ventricular Cardiomyopathy
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Alzheimers Disease
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NCAM signaling for neurite out-growth
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Integration of energy metabolismWP58:Monoamine GPCRs
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GPCRs, OtherWP536:Calcium Regulation in the Cardiac Cell
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Nicotine Activity on Chromaffin CellsWP58:Monoamine GPCRs
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Vitamin D Receptor Pathway
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References |
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 498). |
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REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006771) |
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REF 3 | Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists. |
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REF 4 | J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. |
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REF 5 | J Med Chem. 1995 May 12;38(10):1579-81.Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. |