Drug Information
Drug General Information | |||||
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Drug ID |
D06IFH
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Former ID |
DNC005888
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Drug Name |
JNJ-7777120
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Drug Type |
Small molecular drug
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Indication | Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] | Investigative | [1] | ||
Structure |
Download2D MOL |
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Formula |
C14H16ClN3O
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InChI |
InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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InChIKey |
HUQJRYMLJBBEDO-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
7208642, 8472987, 14799535, 29217572, 39075314, 49846380, 50075249, 57357288, 57818501, 61262560, 78047416, 81123443, 85083127, 89501661, 103361356, 113628387, 125299313, 125333903, 131693053, 134343094, 135262061, 135650446, 135651168, 135697623, 137014298, 143295275, 162009834, 162012011, 162248412, 163123369, 167272760, 174529437, 184629548, 187071988, 198975186, 204370503, 223835200, 226546411, 246996609, 249776624, 250134239, 251970998, 252157719, 252160038, 252450534, 252472158
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Target and Pathway | |||||
Target(s) | Histamine H4 receptor | Target Info | Inhibitor | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Reactome | Histamine receptors | ||||
G alpha (i) signalling events | |||||
WikiPathways | GPCR ligand binding | ||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1278). | ||||
REF 2 | Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. Epub 2010 Mar 3.Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. | ||||
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