Drug Information

Drug General Information
Drug ID
D06IFH
Former ID
DNC005888
Drug Name
JNJ-7777120
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [538790]
Structure
Download
2D MOL
Formula
C14H16ClN3O
InChI
InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
InChIKey
HUQJRYMLJBBEDO-UHFFFAOYSA-N
PubChem Compound ID
4908365
PubChem Substance ID
7208642, 8472987, 14799535, 29217572, 39075314, 49846380, 50075249, 57357288, 57818501, 61262560, 78047416, 81123443, 85083127, 89501661, 103361356, 113628387, 125299313, 125333903, 131693053, 134343094, 135262061, 135650446, 135651168, 135697623, 137014298, 143295275, 162009834, 162012011, 162248412, 163123369, 167272760, 174529437, 184629548, 187071988, 198975186, 204370503, 223835200, 226546411, 246996609, 249776624, 250134239, 251970998, 252157719, 252160038, 252450534, 252472158
Target and Pathway
Target(s) Histamine H4 receptor Target Info Inhibitor [530796]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538790(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1278).
Ref 530796Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. Epub 2010 Mar 3.Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.

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