Drug Information
Drug General Information | |||||
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Drug ID |
D06IIF
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Former ID |
DNC009060
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Drug Name |
1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane
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Synonyms |
1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
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Indication | Discovery agent | Investigative | [529523] | ||
Structure |
Download2D MOL |
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Canonical SMILES |
C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl
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InChI |
1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2
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InChIKey |
BSMNRYCSBFHEMQ-UHFFFAOYSA-N
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Target and Pathway | |||||
Target(s) | Sodium-dependent noradrenaline transporter | Target Info | Inhibitor | [531114] | |
Potassium voltage-gated channel subfamily H member 2 | Target Info | Inhibitor | [529777] | ||
Sodium-dependent dopamine transporter | Target Info | Inhibitor | [529523] | ||
Sodium-dependent serotonin transporter | Target Info | Inhibitor | [529523] | ||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis | ||||
Parkinson disease | |||||
Dopamine receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway | |||||
5HT2 type receptor mediated signaling pathway | |||||
5HT3 type receptor mediated signaling pathway | |||||
5HT4 type receptor mediated signaling pathway | |||||
Pathway Interaction Database | Alpha-synuclein signaling | ||||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
WikiPathways | Monoamine Transport | ||||
NRF2 pathway | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP706:SIDS Susceptibility Pathways | |||||
Hematopoietic Stem Cell Differentiation | |||||
Potassium ChannelsWP727:Monoamine Transport | |||||
Dopaminergic Neurogenesis | |||||
Parkinsons Disease Pathway | |||||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||||
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport | |||||
SIDS Susceptibility Pathways | |||||
Synaptic Vesicle Pathway | |||||
Serotonin Transporter Activity | |||||
References | |||||
Ref 529523 | Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. | ||||
Ref 529777 | Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. Epub 2008 Oct 11.Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. | ||||
Ref 531114 | Bioorg Med Chem Lett. 2010 Sep 15;20(18):5567-71. Epub 2010 Aug 17.Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. |
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