| Drug General Information |
| Drug ID |
D06KNK
|
| Former ID |
DIB019956
|
| Drug Name |
TDZD-8
|
| Synonyms |
TDZD-8
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H10N2O2S
|
| InChI |
InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
|
| InChIKey |
JDSJDASOXWCHPN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
6055436, 8356425, 11108555, 14797987, 26758797, 29217671, 35381791, 47720585, 57356766, 58107448, 76462416, 91610839, 92708299, 99302711, 103192812, 112676838, 124893197, 125580415, 126590965, 134223934, 137232094, 137650937, 152254773, 160833940, 162009856, 162011986, 162248544, 162837469, 163395753, 163688046, 163779005, 163843565, 164836458, 174528910, 175607478, 178102600, 179236131, 184600769, 186014480, 187561549, 202551613, 204394183, 210274741, 210280374, 223366708, 223379791, 223454879, 223519410, 226506996, 242060039
|
| Target and Pathway |
| Target(s) |
Glycogen synthase kinase-3 beta |
Target Info |
Inhibitor |
[2]
|
|---|
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KEGG Pathway
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ErbB signaling pathway
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Chemokine signaling pathway
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Cell cycle
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PI3K-Akt signaling pathway
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Wnt signaling pathway
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Hedgehog signaling pathway
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Axon guidance
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Hippo signaling pathway
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Focal adhesion
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Signaling pathways regulating pluripotency of stem cells
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Insulin signaling pathway
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Melanogenesis
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
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Alzheimer's disease
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Hepatitis C
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Measles
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Influenza A
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HTLV-I infection
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Epstein-Barr virus infection
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Pathways in cancer
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Colorectal cancer
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Endometrial cancer
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Prostate cancer
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Basal cell carcinoma
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PANTHER Pathway
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Alzheimer disease-presenilin pathway
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Angiogenesis
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Cadherin signaling pathway
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Hedgehog signaling pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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Wnt signaling pathway
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Ras Pathway
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CCKR signaling map ST
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|
Pathway Interaction Database
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LPA receptor mediated events
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Degradation of beta catenin
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Reelin signaling pathway
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Presenilin action in Notch and Wnt signaling
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Integrin-linked kinase signaling
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CDC42 signaling events
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LKB1 signaling events
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Canonical Wnt signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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C-MYC pathway
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Regulation of Androgen receptor activity
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BMP receptor signaling
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Hedgehog signaling events mediated by Gli proteins
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Validated transcriptional targets of deltaNp63 isoforms
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Aurora A signaling
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Insulin-mediated glucose transport
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Class I PI3K signaling events mediated by Akt
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p53 pathway
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Trk receptor signaling mediated by PI3K and PLC-gamma
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Reactome
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Degradation of beta-catenin by the destruction complex
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AKT phosphorylates targets in the cytosol
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Regulation of HSF1-mediated heat shock response
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CRMPs in Sema3A signaling
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Disassembly of the destruction complex and recruitment of AXIN to the membrane
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S33 mutants of beta-catenin aren't phosphorylated
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S37 mutants of beta-catenin aren't phosphorylated
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S45 mutants of beta-catenin aren't phosphorylated
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T41 mutants of beta-catenin aren't phosphorylated
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Degradation of GLI2 by the proteasome
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Constitutive Signaling by AKT1 E17K in Cancer
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Senescence and Autophagy in Cancer
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Notch Signaling Pathway
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Glycogen Metabolism
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Insulin Signaling
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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IL-6 signaling pathway
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Wnt Signaling Pathway Netpath
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Copper homeostasis
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Focal Adhesion
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Hair Follicle Development: Induction (Part 1 of 3)
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Cardiac Hypertrophic Response
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Degradation of beta-catenin by the destruction complex
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T-Cell Receptor and Co-stimulatory Signaling
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Cardiac Progenitor Differentiation
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BDNF signaling pathway
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Corticotropin-releasing hormone
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B Cell Receptor Signaling Pathway
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IL17 signaling pathway
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Neural Crest Differentiation
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Alzheimers Disease
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IL-7 Signaling Pathway
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Regulation of Microtubule Cytoskeleton
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TWEAK Signaling Pathway
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Leptin signaling pathway
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Semaphorin interactions
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Cell Cycle
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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IL-5 Signaling Pathway
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| References |
| REF 1 | Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther. 2006 Jan;316(1):17-24. Epub 2005 Sep 16. |
|---|
| REF 2 | Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3beta inhibitors through virtual screening. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7232-6. |
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