Drug General Information
Drug ID
D06KSF
Former ID
DIB021073
Drug Name
Tpl2 kinase inhibitor
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541305]
Structure
Download
2D MOL
Formula
C21H14ClFN6
InChI
InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
InChIKey
NMEUKWOOQOHUNA-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mRNA of human cot oncogene Target Info Inhibitor [527741]
KEGG Pathway MAPK signaling pathway
Toll-like receptor signaling pathway
T cell receptor signaling pathway
TNF signaling pathway
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database TCR signaling in na&#xef
TCR signaling in na&#xef
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Reactome CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
WikiPathways Toll-like receptor signaling pathway
TCR Signaling Pathway
Insulin Signaling
MAPK Signaling Pathway
Structural Pathway of Interleukin 1 (IL-1)
TNF alpha Signaling Pathway
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Interleukin-1 signaling
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathway
References
Ref 541305(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6051).
Ref 527741Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. Epub 2005 Sep 13.

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