Drug General Information
Drug ID
D06KYN
Former ID
DAP000936
Drug Name
Arbutamine
Synonyms
Arbutamina; Arbutaminum; Genesa; Arbutamina [INN-Spanish]; Arbutamine [INN:BAN]; Arbutaminum [INN-Latin]; 4-[(1R)-1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol; 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol; 4-[1-hydroxy-2-[4-(4-hydroxyphenyl)butylamino]ethyl]benzene-1,2-diol
Drug Type
Small molecular drug
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Approved [550707]
Therapeutic Class
Cardiotonic Agents
Structure
Download
2D MOL

3D MOL

Formula
C18H23NO4
Canonical SMILES
C1=CC(=CC=C1CCCCNCC(C2=CC(=C(C=C2)O)O)O)O
InChI
1S/C18H23NO4/c20-15-7-4-13(5-8-15)3-1-2-10-19-12-18(23)14-6-9-16(21)17(22)11-14/h4-9,11,18-23H,1-3,10,12H2
InChIKey
IIRWWTKISYTTBL-UHFFFAOYSA-N
CAS Number
CAS 128470-16-6
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:50580
SuperDrug ATC ID
C01CA22
SuperDrug CAS ID
cas=128470166
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Stimulator [537972]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 550707Drug information of Arbutamine, 2008. eduDrugs.
Ref 537972Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Cardiovasc Drugs Ther. 1996 Mar;10(1):39-47.

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