Drug Information

Drug General Information
Drug ID
D06LRC
Former ID
DNC014193
Drug Name
Isosorbide-di-phenylcarbamate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530646]
Structure
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2D MOL

3D MOL
Formula
C20H20N2O6
Canonical SMILES
C1C(C2C(O1)C(CO2)OC(=O)NC3=CC=CC=C3)OC(=O)NC4=CC=CC=C4
InChI
1S/C20H20N2O6/c23-19(21-13-7-3-1-4-8-13)27-15-11-25-18-16(12-26-17(15)18)28-20(24)22-14-9-5-2-6-10-14/h1-10,15-18H,11-12H2,(H,21,23)(H,22,24)/t15-,16+,17-,18-/m1/s1
InChIKey
KDDHNJSIHIMRGH-XMTFNYHQSA-N
PubChem Compound ID
46232722
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [530646]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 530646Bioorg Med Chem. 2010 Feb;18(3):1045-53. Epub 2010 Jan 6.Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
Ref 530646Bioorg Med Chem. 2010 Feb;18(3):1045-53. Epub 2010 Jan 6.Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.

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