Drug Information

Drug General Information
Drug ID
D06LYG
Former ID
DAP000511
Drug Name
Prilocaine
Synonyms
Citanest; Prilocaina; Prilocainum; Propitocaine; Prilocaine [USAN]; Prilocaine base; Astra 1512; Astra 1515; L 67; Citanest (TN); Prilocaina [INN-Spanish]; Prilocainum [INN-Latin]; Propitocaine (JAN); Prilocaine (USP/INN); O-Methyl-2-propylaminopropionanilide; O-Methyl-alpha-propylaminopropionanilide; Alpha-n-Propylamino-2-methylpropionanilide; N-[2-Methylphenyl]-2-[propylamino]propanamide; N-(2-methylphenyl)-N2-propylalaninamide; N-(2-Methylphenyl)-2-(propylamino)propanamide; N-(2-methylphenyl)-N(2)-propylalaninamide; Propanamide, N-(2-methylphenyl)-2-(propylamino)-(9CI); 2-(Propylamino)-o-propionotoluidide; 2-Methyl-.alpha.-propylaminopropionanilide; 2-Methyl-alpha-propylaminopropionanilide
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Approved [538314], [542296], [551871]
Therapeutic Class
Anesthetics
Company
Astrazeneca Lp
Structure
Download
2D MOL

3D MOL
Formula
C13H20N2O
InChI
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
InChIKey
MVFGUOIZUNYYSO-UHFFFAOYSA-N
CAS Number
CAS 721-50-6
PubChem Compound ID
4906
PubChem Substance ID
9734, 95408, 5227596, 7847619, 7980380, 8153018, 10533889, 11336021, 11361260, 11364543, 11367105, 11369667, 11371923, 11375021, 11377829, 11462232, 11466227, 11467347, 11485134, 11485814, 11489365, 11490867, 11493006, 11495463, 15195949, 29223984, 37645318, 46505066, 47440311, 47515365, 47589045, 47662336, 47662337, 47959796, 48035180, 48185043, 48423995, 49698942, 49856374, 50111213, 50476259, 53790341, 85088898, 85171684, 85788442, 90341069, 92719754, 92729955, 103357947, 104253257
SuperDrug ATC ID
N01BB04
SuperDrug CAS ID
cas=000721506
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Blocker [538082]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 538314FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076290.
Ref 542296(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7276).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 538082Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.

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