Drug Information

Drug General Information
Drug ID
D06ODM
Former ID
DCL000303
Drug Name
Talsaclidine fumarate
Synonyms
Wal 2014 FU; Talsaclidine fumarate (USAN); (E)-but-2-enedioic acid; 1-Azabicyclo(2.2.2)octane, 3-(2-propynyloxy)-, (R)-, (E)-2-butenedioate (1:1); 3-(2-Propynyloxy)-1-azabicyclo(2.2.2)octane 2-butenedioate; 3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Discontinued in Phase 2 [545043]
Company
Boehringer
Structure
Download
2D MOL

3D MOL
Formula
C14H19NO5
Canonical SMILES
C#CCOC1CN2CCC1CC2.C(=CC(=O)O)C(=O)O
InChI
1S/C10H15NO.C4H4O4/c1-2-7-12-10-8-11-5-3-9(10)4-6-11;5-3(6)1-2-4(7)8/h1,9-10H,3-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey
SBCXBWBXWKVIFK-WLHGVMLRSA-N
CAS Number
CAS 147025-54-5
PubChem Compound ID
6439491
PubChem Substance ID
11968312, 43032413, 53252140, 114558818, 134338959, 135087835, 234536447, 234536451
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Agonist [535511], [537030]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 545043Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001956)
Ref 535511Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine. Psychopharmacology (Berl). 2002 Jul;162(3):292-300. Epub 2002 May 29.
Ref 537030Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. Epub 2009 Jan 11.

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