Drug Information

Drug General Information
Drug ID
D06PYP
Former ID
DND000030
Drug Name
JTS-653
Indication Overactive bladder disorder; Pain [ICD9: 188, 596.51, 338, 356.0, 356.8, 780; ICD10:C67, N32.81, G64, G90.0, R52, G89] Discontinued in Phase 2 [548768]
Company
Japan Tobacco
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 548768Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028532)
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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