Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06PYP
|
||||
| Former ID |
DND000030
|
||||
| Drug Name |
JTS-653
|
||||
| Indication | Overactive bladder disorder; Pain [ICD9: 188, 596.51, 338, 356.0, 356.8, 780; ICD10:C67, N32.81, G64, G90.0, R52, G89] | Discontinued in Phase 2 | [1] | ||
| Company |
Japan Tobacco
|
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| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028532) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). | ||||
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