Drug Information

Drug General Information
Drug ID
D06PYV
Former ID
DNC010370
Drug Name
2-amino-3-(m-tolylamino)naphthalene-1,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530650]
Structure
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2D MOL

3D MOL
Formula
C17H14N2O2
Canonical SMILES
CC1=CC(=CC=C1)NC2=C(C(=O)C3=CC=CC=C3C2=O)N
InChI
1S/C17H14N2O2/c1-10-5-4-6-11(9-10)19-15-14(18)16(20)12-7-2-3-8-13(12)17(15)21/h2-9,19H,18H2,1H3
InChIKey
REWOWOXSGLQOHC-UHFFFAOYSA-N
PubChem Compound ID
11976150
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Inhibitor [530650]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 530650J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.
Ref 530650J Med Chem. 2010 Feb 25;53(4):1799-809.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

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