Drug Information

Drug General Information
Drug ID
D06QIQ
Former ID
DNC009141
Drug Name
7-(piperidin-4-ylmethoxy)-2-naphthonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530012]
Structure
Download
2D MOL

3D MOL
Formula
C17H18N2O
Canonical SMILES
C1CNCCC1COC2=CC3=C(C=CC(=C3)C#N)C=C2
InChI
1S/C17H18N2O/c18-11-14-1-2-15-3-4-17(10-16(15)9-14)20-12-13-5-7-19-8-6-13/h1-4,9-10,13,19H,5-8,12H2
InChIKey
ZINGRQZUIVEPKX-UHFFFAOYSA-N
PubChem Compound ID
44592241
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Inhibitor [530012]
Sodium-dependent serotonin transporter Target Info Inhibitor [530012]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530012]
Sodium-dependent dopamine transporter Target Info Inhibitor [530012]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [530012]
KEGG Pathway Serotonergic synapsehsa04726:Serotonergic synapsehsa04728:Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Muscle/Heart Contraction
Reactome Ligand-gated ion channel transportR-HSA-1296072:Voltage gated Potassium channelsR-HSA-442660:Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transportWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium ChannelsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic CleftWP727:Monoamine Transport
References
Ref 530012Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.
Ref 530012Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. Epub 2009 Feb 20.Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.