Drug General Information
Drug ID	D06RID
Former ID	DNC013878
Drug Name	4-(cyclohexyloxy)quinazoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530023]
Structure		Download 2D MOL 3D MOL
Formula	C14H16N2O
Canonical SMILES	C1CCC(CC1)OC2=NC=NC3=CC=CC=C32
InChI	1S/C14H16N2O/c1-2-6-11(7-3-1)17-14-12-8-4-5-9-13(12)15-10-16-14/h4-5,8-11H,1-3,6-7H2
InChIKey	QNXOLVQGDILPJV-UHFFFAOYSA-N
PubChem Compound ID	44591868
Target and Pathway
Target(s)	Metabotropicglutamate receptor 1	Target Info	Inhibitor	[530023]
KEGG Pathway	Calcium signaling pathway
	FoxO signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Long-term depression
	Estrogen signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530023	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. Epub 2009 Mar 3.In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Ref 530023	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. Epub 2009 Mar 3.In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.

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