Drug Information
Drug General Information | |||||
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Drug ID |
D06RNM
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Former ID |
DIB019035
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Drug Name |
burimamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C13H18N4S
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InChI |
InChI=1S/C13H18N4S/c1-14-13(18)15-8-3-2-5-10-6-4-7-12-11(10)9-16-17-12/h4,6-7,9H,2-3,5,8H2,1H3,(H,16,17)(H2,14,15,18)
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InChIKey |
TXQIYKPZFOKCHA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Histamine H4 receptor | Target Info | Antagonist | [2] | |
Histamine H3 receptor | Target Info | Antagonist | [3] | ||
Histamine H2 receptor | Target Info | Agonist | [4] | ||
KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gastric acid secretion | |||||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Histamine H2 receptor mediated signaling pathway | |||||
PathWhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | ||||
Gastric Acid Production | |||||
Reactome | Histamine receptors | ||||
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors | |||||
G alpha (s) signalling events | |||||
WikiPathways | GPCR ligand binding | ||||
GPCR downstream signaling | |||||
GPCRs, OtherWP727:Monoamine Transport | |||||
GPCRs, Class A Rhodopsin-like | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
References | |||||
REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1229). | ||||
REF 2 | Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30. | ||||
REF 3 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. | ||||
REF 4 | Constitutive activity and structural instability of the wild-type human H2 receptor. J Neurochem. 1998 Aug;71(2):799-807. | ||||
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