Drug Information

Drug General Information
Drug ID
D06SDD
Former ID
DIB020351
Drug Name
MGS0028
Synonyms
MGS 0028; MGS-0028
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538871]
Structure
Download
2D MOL
Formula
C8H8FNO5
InChI
InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
InChIKey
KFAGJPNFERWZJA-JKBXLQNXSA-N
PubChem Compound ID
9837317
PubChem Substance ID
14797857, 14822576, 24136338, 44935409, 57373482, 78078101, 103348707, 103992706, 128372949, 135650604, 141002616, 198967495, 223370291, 228564397, 241070626
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Agonist [525933]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538871(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1395).
Ref 525933Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. J Med Chem. 2000 Dec 14;43(25):4893-909.

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