Drug General Information
Drug ID
D06UJA
Former ID
DIB020387
Drug Name
MNI-136
Synonyms
MNI 136
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541390]
Structure
Download
2D MOL
Formula
C21H16BrN3O
InChI
InChI=1S/C21H16BrN3O/c22-17-4-5-19-20(13-17)24-18(6-7-21(26)25-19)16-3-1-2-15(12-16)14-8-10-23-11-9-14/h1-5,8-13H,6-7H2,(H,25,26)/b24-18+
InChIKey
BLAQAVITPVXJJS-HKOYGPOVSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator (allosteric modulator) [528775]
Metabotropic glutamate receptor3 Target Info Modulator (allosteric modulator) [528775]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 541390(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6220).
Ref 528775A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. Epub 2007 Apr 6.

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