Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06UUP
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| Former ID |
DIB001331
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| Drug Name |
NK-3 antagonists
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| Synonyms |
NK-3 antagonists (CNS diseases); NK-3 antagonists (CNS diseases), Lundbeck
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| Indication | Central nervous system disease [ICD10:G00-G99] | Investigative | [1] | ||
| Company |
H Lundbeck A/S
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
S(=O)(=O)(N(C)C)N1CCN(C[C@H]2[C@](c3ccc(c(c3)Cl)Cl)(C2)<br />C(=O)N(C)Cc2ccc(cc2)F)CC1
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| Target and Pathway | |||||
| Target(s) | Nigral tachykinin NK(3) receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Novel NK(3) receptor antagonists for the treatment of schizophrenia and other CNS indications. Curr Opin Drug Discov Devel. 2010 Jul;13(4):379-88. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362). | ||||
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