Drug Information

Drug General Information
Drug ID
D06UXW
Former ID
DNC005816
Drug Name
METHOCTRAMINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540235]
Structure
Download
2D MOL

3D MOL
Formula
C36H62N4O2
InChI
InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
InChIKey
RPMBYDYUVKEZJA-UHFFFAOYSA-N
PubChem Compound ID
4108
PubChem Substance ID
7816806, 7979931, 8152577, 11111402, 26755711, 29223216, 48334730, 50071061, 50111179, 80048344, 85209565, 90341490, 103202841, 103835854, 103959242, 104305449, 117535744, 124750056, 124880614, 124880615, 129163030, 134343021, 135650585, 137440398, 163425990, 179235717, 237109720, 249817744, 249819743
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [527823]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [529789]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP706:SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540235(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 327).
Ref 527823J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Ref 529789J Med Chem. 2008 Nov 27;51(22):7094-8.cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

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