Drug Information

Drug General Information
Drug ID
D06WTZ
Former ID
DAP000551
Drug Name
Lovastatin
Synonyms
Altocor; Altoprev; Artein; Belvas; Cholestra; Closterol; Colevix; Hipolip; Hipovastin; Lestatin; Lipdip; Lipivas; Lipofren; Liposcler; Lovalip; Lovalord; Lovastatina; Lovastatine; Lovastatinum; Lovasterol; Lovastin; Lozutin; Mevacor; Mevinacor; Mevinolin; Mevlor; Nergadan; Paschol; Rextat; Rodatin; Rovacor; Sivlor;Taucor; Tecnolip; Teroltrat; Lovastatina [Spanish]; Lovastatine [French]; Lovastatinum [Latin]; Monacolin K; Monakolin K; MK 803; MK803; MSD 803; Advicor (TN); Altocor (TN); Altoprev (TN); L-154803; Lovastatin & Primycin; MK-803; ML-530B; Mevacor (TN); Mevinolin from Aspergillus sp.; Statosan (TN); Lovastatin (USP/INN); Lovastatin [USAN:BAN:INN]; Lovastatin, (1 alpha(S*))-Isomer; Lovastatin, 1 alpha-Isomer (without R*/S* notation); 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 6 Methylcompactin; 6 alpha-Methylcompactin; 6-Methylcompactin; 6-alpha-Methylcompactin; 6alpha-Methylcompactin
Drug Type
Small molecular drug
Indication Hypercholesterolemia [ICD10:E78] Approved [537114], [539783]
Therapeutic Class
Anticholesteremic Agents
Company
Atos Pharma
Structure
Download
2D MOL

3D MOL
Formula
C24H36O5
InChI
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
InChIKey
PCZOHLXUXFIOCF-BXMDZJJMSA-N
CAS Number
CAS 75330-75-5
PubChem Compound ID
53232
PubChem Substance ID
9285, 496591, 623233, 855905, 7734777, 7847425, 7885508, 7979813, 8150103, 8182985, 10321765, 10852021, 11336207, 11361446, 11372945, 11462418, 11466544, 11467664, 11486128, 11491688, 11528634, 12012664, 12146073, 14806053, 14879393, 17389841, 22395934, 24896706, 25622285, 26612569, 26680612, 26697338, 26751557, 26759065, 34717349, 46391668, 46508223, 47515402, 47589078, 47662390, 47662391, 47662392, 47736583, 47959858, 47959859, 48035229, 48185079, 48334593, 48413948, 48416187
ChEBI ID
ChEBI:40303
SuperDrug ATC ID
C10AA02
SuperDrug CAS ID
cas=075330755
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [535491]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 539783(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2739).
Ref 535491Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46.

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