Drug General Information
Drug ID
D06YFT
Former ID
DIB018509
Drug Name
1-methyl-L-tryptophan
Synonyms
1-L-MT; 1-LMT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528360]
Structure
Download
2D MOL
Formula
C12H14N2O2
InChI
InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1
InChIKey
ZADWXFSZEAPBJS-JTQLQIEISA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [532500]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 528360Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. Biotechnol J. 2006 Mar;1(3):282-8.
Ref 532500Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31.

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