Drug Information

Drug General Information
Drug ID
D06ZAM
Former ID
DNC002655
Drug Name
MF268
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [546262]
Structure
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2D MOL

3D MOL
Formula
C28H46N4O3
Canonical SMILES
CC1CN(CC(O1)C)CCCCCCCCNC(=O)OC2=CC3=C(C=C2)N(C4C3(CCN4C<br />)C)C
InChI
1S/C28H46N4O3/c1-21-19-32(20-22(2)34-21)16-11-9-7-6-8-10-15-29-27(33)35-23-12-13-25-24(18-23)28(3)14-17-30(4)26(28)31(25)5/h12-13,18,21-22,26H,6-11,14-17,19-20H2,1-5H3,(H,29,33)/t21-,22+,26-,28+/m1/s1
InChIKey
CJMJXTWMGXRFOM-FKTURHEWSA-N
PubChem Compound ID
3074013
PubChem Substance ID
9467552, 14908232, 36406252, 49658911, 49899543, 52530127, 111670051, 134224866, 135221301, 228518652, 247863678
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [551374]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 546262Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007171)
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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