Drug Information

Drug General Information
Drug ID
D07EFM
Former ID
DNC002508
Drug Name
Arecoline
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 1 [525796], [526115], [527244], [539971]
Structure
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2D MOL

3D MOL
Formula
C8H13NO2
InChI
InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
InChIKey
HJJPJSXJAXAIPN-UHFFFAOYSA-N
CAS Number
CAS 63-75-2
PubChem Compound ID
2230
PubChem Substance ID
12315, 105753, 593648, 598409, 5260928, 8151508, 10531347, 11110758, 11110759, 11335985, 11361224, 11362849, 11365411, 11367973, 11372293, 11374438, 11376135, 11462196, 11466430, 11467550, 11483937, 11485999, 11487867, 11491202, 11492625, 11493869, 11537666, 15219310, 26755647, 36538750, 46507231, 47216812, 47291178, 47365235, 47515351, 47515352, 47736525, 47959789, 48035165, 48185035, 48334535, 48415577, 49698472, 49997631, 50110935, 50110936, 53789882, 57321212, 78997792, 85209508
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Inhibitor [551393]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 525796Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol. 2000 Mar 31;43(1):23-8.
Ref 526115M1 receptor activation is a requirement for arecoline analgesia. Farmaco. 2001 May-Jul;56(5-7):383-5.
Ref 527244Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol. 2004 Jun 30;47(2):89-94.
Ref 539971(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 296).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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