Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07FTI
|
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| Former ID |
DIB021255
|
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| Drug Name |
zinc pyrithione
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H8N2O2S2Zn
|
||||
| InChI |
InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
|
||||
| InChIKey |
OTPSWLRZXRHDNX-UHFFFAOYSA-L
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Kv7.5 | Target Info | Activator | [2] | |
| Potassium voltage-gated channel subfamily KQT member 4 | Target Info | Activator | [2] | ||
| Potassium voltage-gated channel subfamily KQT member 1 | Target Info | Activator | [2] | ||
| Potassium voltage-gated channel subfamily KQT member 2 | Target Info | Activator | [2] | ||
| KEGG Pathway | Cholinergic synapsehsa04261:Adrenergic signaling in cardiomyocytes | ||||
| Cholinergic synapse | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Protein digestion and absorption | |||||
| Vibrio cholerae infectionhsa04725:Cholinergic synapse | |||||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channels | ||||
| Interaction between L1 and Ankyrins | |||||
| WikiPathways | Potassium ChannelsWP706:SIDS Susceptibility Pathways | ||||
| Potassium Channels | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| TarBasePathwayWP2669:Potassium Channels | |||||
| L1CAM interactions | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2597). | ||||
| REF 2 | Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. Epub 2007 Apr 15. | ||||
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