Drug Information

Drug General Information
Drug ID
D07GRG
Former ID
DNC007065
Drug Name
LY-379268
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538870]
Structure
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2D MOL

3D MOL
Formula
C7H9NO5
InChI
InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
InChIKey
YASVRZWVUGJELU-MDASVERJSA-N
PubChem Compound ID
10197984
PubChem Substance ID
15195268, 15662108, 22590503, 29215549, 40287536, 49999797, 77486515, 91868668, 99431544, 103167684, 103967941, 129768542, 132589503, 134224600, 134344270, 135650556, 135698842, 137009330, 143010681, 163125479, 204369934, 228564400
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Inhibitor [528620]
Metabotropic glutamate receptor 2 Target Info Inhibitor [528620]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 538870(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1394).
Ref 528620J Med Chem. 2007 Jan 25;50(2):233-40.Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.

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