Drug Information

Drug General Information
Drug ID
D07IZF
Former ID
DIB014368
Drug Name
Sch-57790
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [540439], [546916]
Company
Schering-Plough Corp
Structure
Download
2D MOL

3D MOL
Formula
C25H31N3O2S
InChI
InChI=1S/C25H31N3O2S/c1-30-22-9-13-24(14-10-22)31(29)23-11-7-20(8-12-23)25(19-26)28-17-15-27(16-18-28)21-5-3-2-4-6-21/h7-14,21,25H,2-6,15-18H2,1H3
InChIKey
BFELQLHLUNQIHL-UHFFFAOYSA-N
CAS Number
CAS 221660-80-6
PubChem Compound ID
9867750
PubChem Substance ID
14832635, 24159271, 45290014, 79444792, 85224653, 103266270, 103990475, 127506962, 135651029, 142157867, 142275418, 142476128, 226553639
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Antagonist [525433]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540439(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 350).
Ref 546916Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011087)
Ref 525433SCH 57790: a novel M2 receptor selective antagonist. Life Sci. 1999;64(6-7):535-9.

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