Drug Information

Drug General Information
Drug ID
D07JHJ
Former ID
DIB012553
Drug Name
IGANIDIPINE HYDROCHLORIDE
Synonyms
NKY-722; Iganidipine hydrochloride < Rec INNM >; Rac-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl] 5-methyl diester dihydrochloride
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Discontinued in Phase 1 [544613]
Structure
Download
2D MOL

3D MOL
Formula
C28H38N4O6
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)(C)CN2CCN(CC2)CC=C)C3=CC(=<br />CC=C3)[N+](=O)[O-])C(=O)OC
InChI
1S/C28H38N4O6/c1-7-11-30-12-14-31(15-13-30)17-28(4,5)18-38-27(34)24-20(3)29-19(2)23(26(33)37-6)25(24)21-9-8-10-22(16-21)32(35)36/h7-10,16,25,29H,1,11-15,17-18H2,2-6H3
InChIKey
QBTSPDQKRVMTRU-UHFFFAOYSA-N
CAS Number
CAS 119687-33-1
PubChem Compound ID
65936
PubChem Substance ID
8190048, 14763035, 43122671, 53220711, 57315838, 104335066, 117381236, 135025198, 140294598, 142183486, 160703578, 179149652, 184547820, 228159764
Target and Pathway
Target(s) Calcium channel Target Info Blocker [525666], [551871]
References
Ref 544613Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000292)
Ref 525666Improving effects of topical administration of iganidipine, a new calcium channel blocker, on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits. CurrEye Res. 2000 Feb;20(2):101-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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