Drug Information

Drug General Information
Drug ID
D07MVE
Former ID
DIB011519
Drug Name
PD-151832
Synonyms
PD-142505 (racemate); (-)-(R)-(Z)-3-[3-(3-Methoxyphenyl)-2-propynyloxyimino]-1-azabicyclo[2.2.1]heptane
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Discontinued in Phase 1/2 [546217]
Structure
Download
2D MOL

3D MOL
Formula
C16H18N2O2
Canonical SMILES
COc1cccc(c1)C#CCO\\N=C\\2/CN3CCC2C3
InChI
1S/C16H18N2O2/c1-19-15-6-2-4-13(10-15)5-3-9-20-17-16-12-18-8-7-14(16)11-18/h2,4,6,10,14H,7-9,11-12H2,1H3/b17-16+
InChIKey
FXBXWJPMXQHOGD-WUKNDPDISA-N
CAS Number
CAS 149929-38-4
PubChem Compound ID
5487543
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Agonist [551871]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 546217Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006926)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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