Drug General Information
Drug ID	D07OQZ
Former ID	DIB003539
Drug Name	Adenosine A2b antagonists
Synonyms	Adenosine A2b antagonists, Hoffman-La Roche
Indication	Asthma [ICD10:J45]		Investigative	[552096]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=S(=O)(c1cc(C(F)(F)F)ccc1)C1CCN(C(=O)Nc2nc3c(ccc(c3s2)<br />N(CC)C(=O)C)OC)CC1
Target and Pathway
Target(s)	Adenosine A2b receptor	Target Info	Antagonist	[543534]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Alcoholism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552096	Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1933-6
Ref 543534	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20).

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