Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07PZQ
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| Former ID |
DIB020239
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| Drug Name |
L-serine-O-phosphate
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| Synonyms |
LSOP
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C3H8NO6P
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| InChI |
InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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| InChIKey |
BZQFBWGGLXLEPQ-REOHCLBHSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4251, 825453, 841619, 7890432, 7980684, 8145118, 8192381, 11113423, 15340053, 17405445, 24277998, 26751660, 29203220, 43125355, 46505297, 46517825, 47440569, 50068315, 50104360, 50104361, 53777992, 56435316, 56435317, 56435318, 57317099, 57410966, 79764880, 85165191, 85240002, 87574914, 90341677, 91701988, 92298672, 92304275, 103204663, 103843432, 104343198, 117626830, 121361478, 121362097, 124750074, 124886904, 126523129, 127591104, 131331990, 132521938, 135028622, 135651511, 135676490, 136023595
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| Target and Pathway | |||||
| Target(s) | mGlu6 receptor | Target Info | Agonist | [2] | |
| Metabotropic glutamate receptor 4 | Target Info | Agonist | [3] | ||
| Metabotropic glutamate receptor 7 | Target Info | Agonist | [4] | ||
| Metabotropic glutamate receptor 8 | Target Info | Agonist | [5] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Glutamatergic synapse | |||||
| Taste transductionhsa04080:Neuroactive ligand-receptor interaction | |||||
| Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Reactome | G alpha (i) signalling events | ||||
| Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events | |||||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1411). | ||||
| REF 2 | Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52. | ||||
| REF 3 | Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101. | ||||
| REF 4 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | ||||
| REF 5 | Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. | ||||
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