Drug General Information
Drug ID
D07UHS
Former ID
DCL000804
Drug Name
Fingolimod
Synonyms
Gilenya (TN); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol
Drug Type
Small molecular drug
Indication Primary progressive multiple sclerosis [ICD9: 340; ICD10:G35] Approved [531351], [539536]
Company
Novartis
Structure
Download
2D MOL

3D MOL

Formula
C19H33NO2
InChI
InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChIKey
KKGQTZUTZRNORY-UHFFFAOYSA-N
CAS Number
CAS 162359-55-9
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
L04AA27
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Modulator [531351], [536837]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 539536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 536837Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs. 2008 Sep;13(3):465-77.

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