Drug Information

Drug General Information
Drug ID
D07UHY
Former ID
DIB016109
Drug Name
NIK-616
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Terminated [547892]
Company
Kowa Pharmaceutical Co Ltd
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [550628]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [550628]
Type IV phosphodiesterase Target Info Inhibitor [550628]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathway
References
Ref 547892Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020194)
Ref 550628Preclinical trials in Chronic obstructive pulmonary disease in Japan (PO). 2004

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