Drug General Information
Drug ID	D07VZV
Former ID	DIB004109
Drug Name	N-0861
Synonyms	WRC-0006; WRC-0007
Drug Type	Small molecular drug
Indication	Cardiac disease [ICD10:I00-I99]		Discontinued in Phase 3	[545445]
Company	Aderis Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C13H17N5
Canonical SMILES	c12ncn(c1ncnc2N[C@H]1[C@H]2C[C@@H](C1)CC2)C
PubChem Compound ID	6918211
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Antagonist	[527141]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545445	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003285)
Ref 527141	N-0861 selectively antagonizes adenosine A1 receptors in vivo. Eur J Pharmacol. 1992 May 27;216(1):9-16.

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