Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07XPE
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| Former ID |
DAP000206
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| Drug Name |
Phenformin
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| Synonyms |
Azucaps; Cronoformin; DBI; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; Meltrol; Normoglucina; Pedg; Phenethyldiguanide; Phenformine; Phenforminum; Phenformix; Phenylethylbiguanide; Retardo; D Bretard; DB Comb; DBI monohydrochloride; Phenformine HCl; Phenoformine hydrochloride; W 32; Beta-PEBG; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; Db-retard; Debeone (TN); Fenformina [INN-Spanish]; Meltrol-50; N-Phenethylbiguanide hydrochloride; Phenformin (BAN); Phenformin [INN:BAN]; Phenformine [INN-French]; Phenforminum [INN-Latin]; N'-beta-Fenetilformamidiniliminourea; N'-beta-Fenetilformamidiniliminourea [Italian]; N'-beta-Phenethylformamidinylliminourea; N-(2-Phenylethyl)imidodicarbonimidic diamide; PHENFORMIN (SEE ALSO PHENFORMIN HYDROCHLORIDE 834-28-6); 1-(diaminomethylidene)-2-phenethylguanidine; 1-Phenethylbiguanide
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| Drug Type |
Small molecular drug
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| Indication | Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] | Withdrawn from market | [552001] | ||
| Therapeutic Class |
Hypoglycemic Agents
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| Company |
Eli Lilly
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| Structure |
|
Download2D MOL |
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| Formula |
C10H15N5
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| Canonical SMILES |
C1=CC=C(C=C1)CCN=C(N)N=C(N)N
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| InChI |
1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
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| InChIKey |
ICFJFFQQTFMIBG-UHFFFAOYSA-N
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| CAS Number |
CAS 114-86-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9875, 615911, 4583360, 10504499, 11112448, 11364804, 11367366, 11369928, 11372968, 11375528, 11378095, 11466207, 11467327, 11485734, 14773187, 29226965, 46505230, 47217161, 47736859, 47811132, 47960115, 47960116, 48416408, 49698378, 49854764, 50100445, 57288470, 57324876, 78063341, 85787916, 88835501, 94569120, 96025038, 99452969, 103426218, 104098499, 104317320, 117524452, 117879477, 124882390, 124882391, 124882392, 125325517, 125823034, 126687817, 128146967, 131850042, 134223094, 134337521, 134974542
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| SuperDrug ATC ID |
A10BA01
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| SuperDrug CAS ID |
cas=000114863
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| Target and Pathway | |||||
| Target(s) | AMP-activated protein kinase | Target Info | Activator | [535060], [536530], [537950] | |
| KEGG Pathway | FoxO signaling pathway | ||||
| Regulation of autophagy | |||||
| mTOR signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| AMPK signaling pathway | |||||
| Circadian rhythm | |||||
| Insulin signaling pathway | |||||
| Adipocytokine signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Glucagon signaling pathway | |||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| References | |||||
| Ref 535060 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 2000 Oct;10(10):1546-60. | ||||
| Ref 536530 | Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59. | ||||
| Ref 537950 | Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 1996 Jan 12;271(2):611-4. | ||||
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