Drug General Information
Drug ID
D07YLK
Former ID
DCL000862
Drug Name
LE-300
Synonyms
L 8401; LE 300; 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL

Formula
C20H22N2
Canonical SMILES
CN1CCC2=CC=CC=C2CC3=C(CC1)C4=CC=CC=C4N3
InChI
1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
InChIKey
YEWGIGCYIAMFMA-UHFFFAOYSA-N
CAS Number
CAS 274694-98-3
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D(1B) dopamine receptor Target Info Antagonist [536463]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Dopamine receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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