Drug Information
Drug General Information | |||||
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Drug ID |
D08AFD
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Former ID |
DIB013914
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Drug Name |
NP-252
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Synonyms |
3-(Cyclopropylcarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid octyl ester
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Discontinued in Phase 1 | [544612] | ||
Structure |
Download2D MOL |
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Formula |
C26H35N3O5
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Canonical SMILES |
CCCCCCCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2[N+](=O)[O-])C(=O<br />)NC3CC3)C)C
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InChI |
1S/C26H35N3O5/c1-4-5-6-7-8-11-16-34-26(31)23-18(3)27-17(2)22(25(30)28-19-14-15-19)24(23)20-12-9-10-13-21(20)29(32)33/h9-10,12-13,19,24,27H,4-8,11,14-16H2,1-3H3,(H,28,30)
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InChIKey |
IAWVGADTHVEXRD-UHFFFAOYSA-N
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CAS Number |
CAS 132031-81-3
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Calcium channel | Target Info | Blocker | [529006], [551871] | |
References | |||||
Ref 529006 | Pharmacological characteristics of NP-252, a new dihydropyridine slow Ca2+ channel blocker, in isolated rabbit vascular smooth muscle and guinea pig myocardium: vascular selectivity. Eur J Pharmacol.1991 Oct 22;203(3):337-44. | ||||
Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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