Drug Information
Drug General Information | |||||
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Drug ID |
D08CZT
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Former ID |
DNC003968
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Drug Name |
2-Phenyl-3-piperidin-4-yl-1H-indole
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [525940] | ||
Structure |
Download2D MOL |
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Formula |
C19H20N2
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Canonical SMILES |
C1CNCCC1C2=C(NC3=CC=CC=C32)C4=CC=CC=C4
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InChI |
1S/C19H20N2/c1-2-6-15(7-3-1)19-18(14-10-12-20-13-11-14)16-8-4-5-9-17(16)21-19/h1-9,14,20-21H,10-13H2
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InChIKey |
FWPAVENSJPMGJO-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Potassium voltage-gated channel subfamily H member 2 | Target Info | Inhibitor | [526043] | |
5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [525940] | ||
PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Hematopoietic Stem Cell Differentiation | |||||
Potassium ChannelsWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
Monoamine GPCRs | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
GPCRs, Other | |||||
References | |||||
Ref 525940 | Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3.3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. | ||||
Ref 526043 | J Med Chem. 2001 May 10;44(10):1603-14.3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. |
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