Drug Information
Drug General Information | |||||
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Drug ID |
D08DQL
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Former ID |
DIB020568
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Drug Name |
NPPB
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Synonyms |
HOE 144; HOE-144
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [467607] | ||
Structure |
Download2D MOL |
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Formula |
C16H16N2O4
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InChI |
InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
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InChIKey |
WBSMIPAMAXNXFS-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
586294, 6577388, 7978604, 8150027, 8152803, 11111539, 11113585, 11120005, 11120493, 11120981, 11147088, 11335794, 11361033, 11364722, 11367284, 11369846, 11372794, 11373854, 11378010, 11462005, 11485169, 11489293, 11491333, 11492153, 11495628, 14849531, 17405418, 22391556, 24277859, 26680096, 26681498, 26751788, 26751789, 26751790, 26759252, 29223640, 46487922, 46500489, 47216531, 47736204, 48034834, 48184731, 48258946, 50070434, 50071074, 50104479, 50104480, 50104481, 50104482, 50277869
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Target and Pathway | |||||
Target(s) | ClC-7 | Target Info | Blocker (channel blocker) | [531154] | |
Chloride channel protein 2 | Target Info | Blocker (channel blocker) | [543920] | ||
Transient receptor potential cation channel subfamily A member 1 | Target Info | Activator | [530784] | ||
VRAC | Target Info | Blocker (channel blocker) | [543931] | ||
calcium activated channel anoctamin 1 | Target Info | Blocker (channel blocker) | [543928] | ||
Maxi Cl- | Target Info | Blocker (channel blocker) | [531154] | ||
WikiPathways | Iron uptake and transport | ||||
References | |||||
Ref 530784 | NPPB structure-specifically activates TRPA1 channels. Biochem Pharmacol. 2010 Jul 1;80(1):113-21. | ||||
Ref 531154 | The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. | ||||
Ref 543920 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699). | ||||
Ref 543928 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). | ||||
Ref 543931 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). |
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