Drug Information

Drug General Information
Drug ID
D08EOD
Former ID
DAP001253
Drug Name
Methsuximide
Synonyms
Celontin; Mesuximid; Mesuximida; Mesuximide; Mesuximidum; Methsuximid; Metosuccimmide; Metsuccimide; Petinutin; Methsuximide [BAN]; Metosuccimmide [DCIT]; PM 396; Alpha-Methylphensuximide; Celontin (TN); Mesuximida [INN-Spanish]; Mesuximide (INN); Mesuximidum [INN-Latin]; Methsuximide (USP); Petinutin (TN); Alpha-Methyl-alpha-phenyl N-methyl succinimide; N,2-Dimethyl-2-phenylsuccinimide; N-Methyl-alpha-methyl-alpha-phenylsuccinimide; (+-)-N,2-Dimethyl-2-phenylsuccinimide; (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion; 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine; 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione; 1,3-Dimethyl-3-phenylsuccinimide; 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
Drug Type
Small molecular drug
Indication Epileptic seizures [ICD9: 345.9, 780.3; ICD10:G40, P90, R56] Approved [538431], [542243]
Therapeutic Class
Anticonvulsants
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C12H13NO2
InChI
InChI=1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3
InChIKey
AJXPJJZHWIXJCJ-UHFFFAOYSA-N
CAS Number
CAS 77-41-8
PubChem Compound ID
6476
PubChem Substance ID
7784245, 7847470, 7979936, 8154134, 10535562, 15171756, 29225451, 46505339, 48416252, 50048511, 57323472, 80615582, 92714623, 103193143, 104312168, 117476298, 121362356, 124899410, 126408324, 126629476, 126678061, 127417438, 134221929, 134338490, 134972484, 140288923, 144076268, 144207162, 144224652, 152101592, 160967839, 163118037, 164762136, 164762137, 175611120, 177513111, 178103802, 179225910, 204425454, 223366887, 223681174, 226421231, 241142344, 249582230, 249991606
SuperDrug ATC ID
N03AD03
SuperDrug CAS ID
cas=000077418
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Blocker [535283]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
Type II diabetes mellitus
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin Cells
References
Ref 538431FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 010596.
Ref 542243(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7228).
Ref 535283Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001 Nov;60(5):1121-32.

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