Drug Information
Drug General Information | |||||
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Drug ID |
D08ESA
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Former ID |
DIB006395
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Drug Name |
CI-966
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Synonyms |
1-[2-[Bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C23H21F6NO3
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InChI |
InChI=1S/C23H21F6NO3/c24-22(25,26)18-7-3-15(4-8-18)20(16-5-9-19(10-6-16)23(27,28)29)33-13-12-30-11-1-2-17(14-30)21(31)32/h2-10,20H,1,11-14H2,(H,31,32)
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InChIKey |
CMHQDSBIBSKHFP-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Sodium- and chloride-dependent GABA transporter 1 | Target Info | Modulator | [533771] | |
KEGG Pathway | GABAergic synapse | ||||
WikiPathways | Monoamine Transport | ||||
NRF2 pathway | |||||
References | |||||
Ref 467852 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4612). | ||||
Ref 533771 | Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. |
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