Drug General Information
Drug ID
D08EXR
Former ID
DIB018964
Drug Name
beta-ergocriptine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543349]
Structure
Download
2D MOL
Formula
C32H41N5O5
InChI
InChI=1S/C32H41N5O5/c1-6-18(4)27-29(39)36-12-8-11-25(36)32(41)37(27)30(40)31(42-32,17(2)3)34-28(38)20-13-22-21-9-7-10-23-26(21)19(15-33-23)14-24(22)35(5)16-20/h7,9-10,13,15,17-18,20,24-25,27,33,41H,6,8,11-12,14,16H2,1-5H3,(H,34,38)/t18-,20+,24+,25-,27+,31+,32-/m0/s1
InChIKey
YYWXOXLDOMRDHW-SGVWFJRMSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D(1B) dopamine receptor Target Info Agonist [529311]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Dopamine receptor mediated signaling pathway
Reactome Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543349(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 988).
Ref 529311Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.

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