Drug Information

Drug General Information
Drug ID
D08FOC
Former ID
DNC001081
Drug Name
Oxotremorine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540029]
Structure
Download
2D MOL

3D MOL
Formula
C12H18N2O
InChI
InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
InChIKey
RSDOPYMFZBJHRL-UHFFFAOYSA-N
CAS Number
CAS 17360-35-9
PubChem Compound ID
4630
PubChem Substance ID
9688, 459069, 3135307, 5204099, 7979247, 8152842, 11111578, 11113735, 11335585, 11360824, 11364342, 11364805, 11366904, 11367367, 11369466, 11369929, 11372797, 11374542, 11377628, 11378096, 11461796, 11485212, 11489384, 11491414, 11492727, 11495262, 11495689, 15121093, 26732553, 26751921, 29223719, 47365120, 47662212, 47810683, 47885342, 48334423, 50039957, 50104597, 50237746, 53786784, 57322362, 85209959, 85787108, 90341593, 92308793, 103088501, 103156731, 103165591, 103918252, 104306964
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Agonist [535589]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540029(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 302).
Ref 535589Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93.

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