Drug Information

Drug General Information
Drug ID
D08FUK
Former ID
DNC011050
Drug Name
(R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551219]
Structure
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2D MOL

3D MOL
Formula
C12H16N2
Canonical SMILES
CC1=CC2=C(C=C1)N(C=C2)CC(C)N
InChI
1S/C12H16N2/c1-9-3-4-12-11(7-9)5-6-14(12)8-10(2)13/h3-7,10H,8,13H2,1-2H3
InChIKey
WETMFNBRIOBNTK-UHFFFAOYSA-N
PubChem Compound ID
10845306
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [551219]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [551219]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.
Ref 551219Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.

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