Drug General Information
Drug ID
D08HGK
Former ID
DNC011494
Drug Name
N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide
Synonyms
N-benzyl-2-(1H-indol-3-yl)-2-oxoacetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528709]
Structure
Download
2D MOL

3D MOL

Formula
C17H14N2O2
Canonical SMILES
C1=CC=C(C=C1)CNC(=O)C(=O)C2=CNC3=CC=CC=C32
InChI
1S/C17H14N2O2/c20-16(14-11-18-15-9-5-4-8-13(14)15)17(21)19-10-12-6-2-1-3-7-12/h1-9,11,18H,10H2,(H,19,21)
InChIKey
HWOWPGLTTSFLOQ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528709]
Gamma-aminobutyric acid receptor Target Info Inhibitor [534710]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528709J Med Chem. 2007 Apr 5;50(7):1627-34. Epub 2007 Mar 3.Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Ref 528709J Med Chem. 2007 Apr 5;50(7):1627-34. Epub 2007 Mar 3.Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Ref 534710J Med Chem. 1998 Sep 24;41(20):3821-30.N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.

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