Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08HPL
|
||||
| Former ID |
DIB018609
|
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| Drug Name |
3S,4R-293B
|
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| Synonyms |
chromanol 239B
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H20N2O4S
|
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| InChI |
InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m1/s1
|
||||
| InChIKey |
HVSJHHXUORMCGK-KGLIPLIRSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Potassium voltage-gated channel subfamily KQT member 1 | Target Info | Blocker (channel blocker) | [1] | |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | ||||
| Cholinergic synapse | |||||
| Gastric acid secretion | |||||
| Pancreatic secretion | |||||
| Protein digestion and absorption | |||||
| Vibrio cholerae infection | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Voltage gated Potassium channels | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Potassium Channels | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| TarBasePathway | |||||
| References | |||||
| REF 1 | A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54. | ||||
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