Drug General Information
Drug ID
D08KDP
Former ID
DNC000257
Drug Name
AS-8112
Indication Emesis [ICD9: 787; ICD10:R11] Terminated [546591]
Company
Dainippon
CAS Number
CAS 13074-00-5
Target and Pathway
Target(s) 5-hydroxytryptamine receptor 3A Target Info Antagonist [536188]
D(3) dopamine receptor Target Info Antagonist [536188]
KEGG Pathway Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transportR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transportWP58:Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 546591Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009088)
Ref 536188Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51.

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