Drug Information

Drug General Information
Drug ID
D08NKJ
Former ID
DNC000709
Drug Name
Guanine
Drug Type
Small molecular drug
Indication Discovery agent Phase 3 [467793], [521421]
Structure
Download
2D MOL

3D MOL
Formula
C5H5N5O
InChI
InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChIKey
UYTPUPDQBNUYGX-UHFFFAOYSA-N
CAS Number
CAS 73-40-5
PubChem Compound ID
764
PubChem Substance ID
2779, 3541, 585679, 594396, 618937, 832638, 833698, 836921, 841460, 854934, 854953, 855322, 1433762, 3133367, 4491989, 4963597, 5161786, 6184055, 7004212, 7377195, 7644358, 7888029, 8022280, 8145637, 8150777, 10534208, 11416826, 14891624, 16020045, 16105542, 24277513, 24439126, 24697815, 24697817, 24697819, 24697820, 24697835, 24697922, 24895044, 24895050, 24895274, 25622131, 26683839, 26711837, 26712763, 26713089, 26717511, 26717514, 26750333, 26750346
ChEBI ID
ChEBI:16235
Target and Pathway
Target(s) GTP cyclohydrolase I Target Info Inhibitor [535179]
PathWhiz Pathway Pterine Biosynthesis
Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
References
Ref 467793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4556).
Ref 521421ClinicalTrials.gov (NCT00001100) A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital Cytomegalovirus (CMV) Infections.. U.S. National Institutes of Health.
Ref 535179GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73.

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