Drug Information

Drug General Information
Drug ID
D08OLP
Former ID
DNC003815
Drug Name
2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526118]
Structure
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2D MOL

3D MOL
Formula
C15H14N3O+
Canonical SMILES
C1=CC=C(C(=C1)C2=CC3=C(N2)C=CC(=C3)C(=N)N)O
InChI
1S/C15H13N3O/c16-15(17)9-5-6-12-10(7-9)8-13(18-12)11-3-1-2-4-14(11)19/h1-8,18-19H,(H3,16,17)
InChIKey
JPGNPKIYCTXJPG-UHFFFAOYSA-N
PubChem Compound ID
1507
Target and Pathway
Target(s) Trypsin Target Info Inhibitor [526118]
Coagulation factor IIa Target Info Inhibitor [526118]
Plasminogen Target Info Inhibitor [526118]
Urokinase-type plasminogen activator Target Info Inhibitor [526118]
Tissue-type plasminogen activator Target Info Inhibitor [526118]
KEGG Pathway Neuroactive ligand-receptor interaction
Pancreatic secretion
Protein digestion and absorption
Influenza Ahsa04080:Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
Influenza Ahsa04064:NF-kappa B signaling pathway
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancerhsa04610:Complement and coagulation cascades
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
EGFR1 Signaling PathwayNetPath_17:IL5 Signaling Pathway
PANTHER Pathway Blood coagulationP00011:Blood coagulation
Plasminogen activating cascadeP00011:Blood coagulation
Plasminogen activating cascade
CCKR signaling map STP00011:Blood coagulation
Pathway Interaction Database Thrombin/protease-activated receptor (PAR) pathway
Angiopoietin receptor Tie2-mediated signaling
FOXA2 and FOXA3 transcription factor networks
PAR4-mediated thrombin signaling events
Syndecan-4-mediated signaling events
PAR1-mediated thrombin signaling eventsangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingintegrin1_pathway:Beta1 integrin cell surface interactions
E2F transcription factor network
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
ATF-2 transcription factor network
AP-1 transcription factor network
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
FGF signaling pathwayamb2_neutrophils_pathway:amb2 Integrin signaling
PathWhiz Pathway Vitamin K Metabolism
CoagulationPW000562:CoagulationPW000562:Coagulation
Reactome Activation of Matrix Metalloproteinases
Cobalamin (Cbl, vitamin B12) transport and metabolismR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)R-HSA-114608:Platelet degranulation
Degradation of the extracellular matrix
Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin Clot
WikiPathways Activation of Matrix MetalloproteinasesWP558:Complement and Coagulation Cascades
Regulation of Actin Cytoskeleton
IL1 and megakaryotyces in obesity
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
Thrombin signalling through proteinase activated receptors (PARs)
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signaling
Formation of Fibrin Clot (Clotting Cascade)
Cell surface interactions at the vascular wall
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
Human Complement System
Activation of Matrix Metalloproteinases
Dissolution of Fibrin Clot
Selenium Micronutrient NetworkWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Endochondral Ossification
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Osteopontin SignalingWP615:Senescence and Autophagy in Cancer
Selenium Micronutrient Network
References
Ref 526118J Med Chem. 2001 Aug 16;44(17):2753-71.Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.
Ref 526118J Med Chem. 2001 Aug 16;44(17):2753-71.Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

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